Article
Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative.
American journal of medical genetics - 27 Feb 1995
Bennett C, Crawford F, Osborne A, Diaz P, Hoyne J, Lopez R, Roques P, Duara R, Rossor M, Mullan M
Abstract excerpt
An association has been observed in several independent data sets between late onset Alzheimer's Disease (AD) and the APOE locus on chromosome 19. We have examined the genotype in family history positive (FHP) and family history negative (FHN) cases and find a distortion of the APOE allele frequencies in accord with previous studies. However, when we examined the allele distribution of the at-risk siblings of the...
Topics
- Age Factors
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Base Sequence
- Case-Control Studies
- Chromosomes, Human, Pair 19