Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E genotypes do not influence the age of onset in Huntington's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2004

Saft C, Andrich J E, Brune N, Gencik M, Kraus P H, Przuntek H, Epplen J T

Abstract excerpt

OBJECTIVE: The epsilon4 allele of the apolipoprotein E (ApoE) gene has been defined as a critical factor for early onset neurodegeneration in Pick's, Parkinson's, and Alzheimer's disease. Unexpectedly, the epsilon4 allele appeared to delay the age of onset in Huntington's disease (HD) patients. Furthermore, sex specific effects were reported on earlier age of onset due to the ApoE epsilon2epsilon3 genotype in...

Topics

Adult
Age of Onset
Apolipoproteins E
Female
Genotype
Humans
Huntington Disease
Male
Middle Aged
Polymerase Chain Reaction
Sex Factors
Trinucleotide Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 15548484
DOI: 10.1136/jnnp.2003.022756
PMCID: PMC1738834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E genotypes do not influence the age of onset in Huntington's disease.PMID 15548484Read ↗

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length.Semantic proximity Read ↗

Apolipoprotein E and presenilin-1 genotypes in Huntington's disease.Semantic proximity Read ↗

Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy.Semantic proximity Read ↗

Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology.Semantic proximity Read ↗

Apolipoprotein E polymorphism in German patients with frontotemporal degeneration.Semantic proximity Read ↗

Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes.Semantic proximity Read ↗

Age at onset of Parkinson disease and apolipoprotein E genotypes.Semantic proximity Read ↗

Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease.Semantic proximity Read ↗

APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.Semantic proximity Read ↗

Parkinson's disease and apolipoprotein E: possible association with dementia but not age at onset.Semantic proximity Read ↗

Mutation size and age at onset in Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.