Article
Age of onset in familial early onset Alzheimer's disease correlates with genetic aetiology.
American journal of medical genetics - 15 Oct 1993
Mullan M, Houlden H, Crawford F, Kennedy A, Rogues P, Rossor M
Abstract excerpt
Age of onset is the most robust clinical feature demarcating aetiologic subtypes of familial Alzheimer's disease. It has previously been noted that early onset disease (arbitrarily below the age of 65 years) conforms to an autosomal dominant pattern of transmission. Late onset disease is generall...
Topics
- Adult
- Age of Onset
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Chromosomes, Human, Pair 14
- Genetic Linkage
- Humans
- Middle Aged
- Mutation