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Article

Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1994

Schlissel M S, Morrow T

Abstract excerpt

The membrane-associated form of Ig heavy chain (mu) protein has been implicated as a critical regulator of B cell development. Mutant mice unable to produce the membrane form of mu protein fail to produce mature B cells. Splenic B cells from mice transgenic for a functionally rearranged Ig mu gene show a marked decrease in endogenous heavy chain gene rearrangement. We have analyzed the effects of a human mu...

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PMID: 8046237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination.PMID 8046237Read ↗

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