Article
Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1994
Schlissel M S, Morrow T
Abstract excerpt
The membrane-associated form of Ig heavy chain (mu) protein has been implicated as a critical regulator of B cell development. Mutant mice unable to produce the membrane form of mu protein fail to produce mature B cells. Splenic B cells from mice transgenic for a functionally rearranged Ig mu gen...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Base Sequence
- Cell Differentiation
- DNA Primers
- Female
- Gene Expression Regulation
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Gestational Age
- Immunoglobulin Heavy Chains
- Immunoglobulin kappa-Chains
- Immunoglobulin mu-Chains
- Liver
- Male
- Mice
- Mice, Inbred BALB C