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Article

lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.

The Journal of experimental medicine - 1 Mar 1995

Roth P E, Kurtz B, Lo D, Storb U

Abstract excerpt

gamma 2b transgenic mice have a severe B cell defect, apparently caused by strong feedback inhibition of endogenous H-gene rearrangement coupled with an inability of gamma 2b to provide the survival/maturation functions of mu. A unique gamma 2b transgenic line, named the C line, was found to permit B cell development. When the C line is crossed with a mu-membrane knockout line, gamma 2b+ B cells develop in the...

Topics

Alleles
Animals
B-Lymphocytes
Base Sequence
Chromosome Mapping
Genes, Immunoglobulin
Hematopoietic Stem Cells
Immunoglobulin M
Immunoglobulin gamma-Chains
Immunoglobulin lambda-Chains
Immunoglobulin mu-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Molecular Sequence Data

RNA, Messenger

Receptors, Antigen, B-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 7869028
DOI: 10.1084/jem.181.3.1059
PMCID: PMC2191911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7869028-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.PMID 7869028Read ↗

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