Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.

The Journal of experimental medicine - 1 Mar 1995

Roth P E, Kurtz B, Lo D, Storb U

Abstract excerpt

gamma 2b transgenic mice have a severe B cell defect, apparently caused by strong feedback inhibition of endogenous H-gene rearrangement coupled with an inability of gamma 2b to provide the survival/maturation functions of mu. A unique gamma 2b transgenic line, named the C line, was found to permit B cell development. When the C line is crossed with a mu-membrane knockout line, gamma 2b+ B cells develop in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to B-Lymphocytes
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Mice, Transgenic

Share to Molecular Sequence Data

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 7869028
DOI: 10.1084/jem.181.3.1059
PMCID: PMC2191911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.PMID 7869028Read ↗

Early B cell development requires mu signaling.Semantic proximity Read ↗

A critical role of lambda 5 protein in B cell development.Semantic proximity Read ↗

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.Semantic proximity Read ↗

Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination.Semantic proximity Read ↗

Epstein-Barr Virus LMP2A-Induced B-Cell Survival in Two Unique Classes of EμLMP2A Transgenic MiceSemantic proximity Read ↗

Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.Semantic proximity Read ↗

Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines.Semantic proximity Read ↗

Role of mu heavy chain in B cell development. I. Blocked B cell maturation but complete allelic exclusion in the absence of Ig alpha/beta.Semantic proximity Read ↗

The role of Ig beta in precursor B cell transition and allelic exclusion.Semantic proximity Read ↗

The type B leukemogenic virus truncated superantigen is dispensable for T-cell lymphomagenesis.Semantic proximity Read ↗

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.Semantic proximity Read ↗

VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.