Article
Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line.
Molecular and cellular biology - 1 Sept 1993
Shapiro A M, Schlissel M S, Baltimore D, DeFranco A L
Abstract excerpt
B-lymphocyte development exhibits a characteristic order of immunoglobulin gene rearrangements. Previous work has led to the hypothesis that expression of the immunoglobulin mu heavy chain induces rearrangement activity at the kappa light-chain locus. To examine this issue in more detail, we isol...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Cell Differentiation
- Cell Line
- DNA Nucleotidyltransferases
- Gene Expression Regulation
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Immunoglobulin kappa-Chains
- Immunoglobulin mu-Chains
- Integrases
- Mice
- RNA, Messenger
- Recombinases
- Transcription, Genetic
- Transfection