Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria.

doi:10.1083/jcb.123.4.921

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Article

Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria.

The Journal of cell biology - 1 Nov 1993

Asahina I, Sampath T K, Nishimura I, Hauschka P V

Abstract excerpt

Osteogenetic protein-1 (OP-1), a member of the TGF-beta superfamily, induces endochondrial bone formation at subcutaneous sites in vivo and stimulates osteoblastic phenotypic expression in vitro. Primary cultures of newborn rat calvarial cells contain a spectrum of osteogenic phenotypes ranging f...

Topics

Alkaline Phosphatase
Animals
Animals, Newborn
Ascorbic Acid
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins
Cartilage
Cell Differentiation
Cell Division
Glycerophosphates
Humans
Osteoblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteocalcin

Phenotype

Proteins

Rats

Rats, Sprague-Dawley

Skull

Source

Open in PubMed Open full text

Identifiers

PMID: 8227149
DOI: 10.1083/jcb.123.4.921
PMCID: PMC2200148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8227149-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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