Article
Molecular characterization of SIG1, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction.
The EMBO journal - 1 Jul 1994
Leberer E, Dignard D, Harcus D, Whiteway M, Thomas D Y
Abstract excerpt
Two recessive mutations in the Saccharomyces cerevisiae SIG1 (suppressor of inhibitory G-protein) gene have been identified by their ability to suppress the signalling defect of dominant-negative variants of the mating response G-protein beta-subunit. The mutations and deletion of SIG1 enhance th...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- DNA, Fungal
- Fungal Proteins
- GTP-Binding Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Mating Factor
- Membrane Proteins
- Mitogen-Activated Protein Kinases
- Models, Biological
- Molecular Sequence Data