Suppression of a dominant G-protein beta-subunit mutation in yeast by G alpha protein expression.

Abstract excerpt

SCG1/GPA1, STE4 and STE18 encode the alpha, beta and gamma components of the G protein involved in mating pheromone signal transduction in Saccharomyces cerevisiae. Responses, including G1 arrest and expression of genes such as FUS1, are activated by beta gamma, which is negatively controlled by alpha(GDP). We previously demonstrated that overexpression of Scg1 suppresses responses to alpha factor and that...

Topics

• Cell Cycle
• Fungal Proteins
• GTP-Binding Protein alpha Subunits
• GTP-Binding Protein alpha Subunits, Gq-G11
• GTP-Binding Protein beta Subunits
• GTP-Binding Protein gamma Subunits
• GTP-Binding Proteins
• Gene Expression Regulation, Fungal
• Genes, Fungal
• Genes, Suppressor