Article
G protein mutations that alter the pheromone response in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Sept 1990
Stone D E, Reed S I
Abstract excerpt
The GPA1 gene of Saccharomyces cerevisiae encodes a G alpha protein that couples the membrane-bound pheromone receptors to downstream elements in the mating response pathway. We have isolated seven mutant alleles of GPA1 that confer pheromone resistance: G50D (a glycine-to-aspartate change at pos...
Topics
- Alleles
- Amino Acid Sequence
- GTP-Binding Proteins
- Genes, Fungal
- Kinetics
- Mating Factor
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptides
- Pheromones
- Plasmids
- Protein Conformation
- Restriction Mapping
- Saccharomyces cerevisiae
- Sequence Homology, Nucleic Acid