Article
The mating-specific G(alpha) protein of Saccharomyces cerevisiae downregulates the mating signal by a mechanism that is dependent on pheromone and independent of G(beta)(gamma) sequestration.
Molecular and cellular biology - 1 Nov 1996
Stratton H F, Zhou J, Reed S I, Stone D E
Abstract excerpt
It has been inferred from compelling genetic evidence that the pheromone-responsive G(alpha) protein of Saccharomyces cerevisiae, Gpa1, directly inhibits the mating signal by binding to its own beta(gamma) subunit. Gpa1 has also been implicated in a distinct but as yet uncharacterized negative re...
Topics
- Alleles
- Cell Cycle
- G1 Phase
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- GTP-Binding Proteins
- Genes, Fungal
- Heterotrimeric GTP-Binding Proteins
- Kinetics
- Mating Factor
- Mutagenesis, Site-Directed
- Peptides
- Pheromones