Article
Switch-domain mutations in the Saccharomyces cerevisiae G protein alpha-subunit Gpa1p identify a receptor subtype-biased mating defect.
Molecular & general genetics : MGG - 1 Apr 1998
DeSimone S M, Kurjan J
Abstract excerpt
The response to pheromone in Saccharomyces cerevisiae involves a heterotrimeric G protein composed of Gpa1p (alpha subunit), Ste4p (beta) and Ste18p (gamma). The switch II region of G alpha subunits is involved in several protein-protein interactions and an intrinsic GTPase activity. To investiga...
Topics
- Fungal Proteins
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- GTP-Binding Proteins
- Genes, Fungal
- Genes, Switch
- Heterotrimeric GTP-Binding Proteins
- Phenotype
- Point Mutation
- Protein Conformation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sex Attractants