Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.

doi:10.1038/ncb1174

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.

Nature cell biology - 1 Oct 2004

Escoté Xavier, Zapater Meritxell, Clotet Josep, Posas Francesc

Abstract excerpt

Activation of stress-activated protein kinases (SAPKs) is essential for proper cell adaptation to extracellular stimuli. The exposure of yeast cells to high osmolarity, or mutations that lead to activation of the Hog1 SAPK, result in cell-cycle arrest. The mechanisms by which Hog1 and SAPKs in ge...

Topics

Alleles
Antibodies, Monoclonal
Cyclin-Dependent Kinase Inhibitor Proteins
Cyclins
Enzyme Activation
G1 Phase
Gene Expression Regulation, Fungal
Mitogen-Activated Protein Kinases
Mutation
Osmotic Pressure
Phosphorylation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Two-Hybrid System Techniques

Source

Open in PubMed

Identifiers

PMID: 15448699
DOI: 10.1038/ncb1174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15448699-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics