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Article

Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.

Nature cell biology - 1 Oct 2004

Escoté Xavier, Zapater Meritxell, Clotet Josep, Posas Francesc

Abstract excerpt

Activation of stress-activated protein kinases (SAPKs) is essential for proper cell adaptation to extracellular stimuli. The exposure of yeast cells to high osmolarity, or mutations that lead to activation of the Hog1 SAPK, result in cell-cycle arrest. The mechanisms by which Hog1 and SAPKs in general regulate cell-cycle progression are not completely understood. Here we show that Hog1 regulates cell cycle...

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PMID: 15448699
DOI: 10.1038/ncb1174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.PMID 15448699Read ↗

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.Semantic proximity Read ↗

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Mitogen-activated protein kinase Hog1 mediates adaptation to G1 checkpoint arrest during arsenite and hyperosmotic stress.Semantic proximity Read ↗

Coordinated control of replication and transcription by a SAPK protects genomic integrity.Semantic proximity Read ↗

Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.Semantic proximity Read ↗

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.Semantic proximity Read ↗

Regulation of mitotic spindle disassembly by an environmental stress-sensing pathway in budding yeast.Semantic proximity Read ↗

Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.Semantic proximity Read ↗

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Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle controlSemantic proximity Read ↗

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