Article
Structure and mechanism of interleukin-1 beta converting enzyme.
Nature - 28 Jul 1994
Wilson K P, Black J A, Thomson J A, Kim E E, Griffith J P, Navia M A, Murcko M A, Chambers S P, Aldape R A, Raybuck S A
Abstract excerpt
Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffractio...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Caspase 1
- Catalysis
- Cell Death
- Cell Line
- Crystallography, X-Ray
- Enzyme Activation
- Humans
- Interleukin-1
- Kinetics
- Metalloendopeptidases
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Protein Folding