Article
Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury.
The Journal of experimental medicine - 3 Mar 1997
Friedlander R M, Gagliardini V, Hara H, Fink K B, Li W, MacDonald G, Fishman M C, Greenberg A H, Moskowitz M A, Yuan J
Abstract excerpt
To explore the role of the interleukin (IL)-1 beta converting enzyme (ICE) in neuronal apoptosis, we designed a mutant ICE gene (C285G) that acts as a dominant negative ICE inhibitor. Microinjection of the mutant ICE gene into embryonal chicken dorsal root ganglial neurons inhibits trophic factor withdrawal-induced apoptosis. Transgenic mice expressing the fused mutant ICE-lacZ gene under the control of the...
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