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Article

Production of a biologically active human interleukin 18 requires its prior synthesis as PRO-IL-18.

Cytokine - 1 Oct 2000

Liu B, Novick D, Kim S H, Rubinstein M

Abstract excerpt

Interleukin (IL-)18 is an activator of NK cells and a co-inducer of Th(1)cytokines, sharing structural features with the IL-1 family of proteins. Unlike most other cytokines, IL-18 and IL-1beta lack a signal peptide, have an all beta-pleated sheet structure and are synthesized as biologically inactive precursors (pro-IL-18 and pro-IL-1beta). These precursors are cleaved by caspase-1 (IL-1beta-converting enzyme,...

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PMID: 11023667
DOI: 10.1006/cyto.2000.0749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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