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Article

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1 Dec 1995

Abstract excerpt

Proteolytic cleavage of key substrates appears to be an important biochemical mechanism underlying the apoptotic process, and the centrality of interleukin 1 beta-converting enzyme (ICE)-like proteases as mediators of apoptosis has been suggested. The identification of the relevant substrates of the ICE protease family during apoptosis therefore constitutes a major challenge. Using human autoantibodies, we...

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PMID: 7500007
DOI: 10.1084/jem.182.6.1625

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