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Article

Current knowledge on procaspase-1 variants with reduced or abrogated enzymatic activity in autoinflammatory disease.

Current rheumatology reports - 1 Jul 2015

Luksch Hella, Winkler Stefan, Heymann Michael C, Schulze Felix, Hofmann Sigrun R, Roesler Joachim, Rösen-Wolff Angela

Abstract excerpt

Caspase-1 is a proinflammatory enzyme that is essential in many inflammatory conditions including infectious, autoimmune, and autoinflammatory disorders. The inflammation is mainly mediated by the generation of inflammasomes that activate caspase-1 and subsequently interleukin (IL)-1β and IL-18. In addition, homotypic CARD/CARD interaction of procaspase-1 with RIP2 and thereby activation of the NF-κB pathways may...

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Source

Identifiers

PMID: 26003867
DOI: 10.1007/s11926-015-0520-5

Genes

CASP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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