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Article

The TACE zymogen: re-examining the role of the cysteine switch.

Cell biochemistry and biophysics - 1 Jan 2006

Milla Marcos E, Gonzales Patricia E, Leonard Jennifer D

Abstract excerpt

The tumor necrosis factor-alpha-converting enzyme (TACE) is a member of the disintegrin family of metalloproteinases (ADAMs) that plays a central role in the regulated shedding of a host of cell surface proteins. TACE is biosynthesized as a precursor protein with latent proteolytic activity (zymogen). TACE's zymogen inhibition is mediated by its Pro domain, a 197-amino acid region that serves this function as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16679521
DOI: 10.1385/CBB:44:3:342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The TACE zymogen: re-examining the role of the cysteine switch.PMID 16679521Read ↗

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The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition.Semantic proximity Read ↗

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