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Article

Functional implications of interleukin-1 beta based on the three-dimensional structure.

Proteins - 1 Jan 1992

Veerapandian B, Gilliland G L, Raag R, Svensson A L, Masui Y, Hirai Y, Poulos T L

Abstract excerpt

The molecular structure of interleukin-1 beta, a hormone-like cytokine with roles in several disease processes, has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. The framework of this molecule consists of 12 antiparallel beta-strands exhibiting pseudo-3-fold symmetry. Six of the strands make up a beta-barrel with polar residues concentrated at either end. Analysis of the...

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PMID: 1553379
DOI: 10.1002/prot.340120103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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