Article
Functional implications of interleukin-1 beta based on the three-dimensional structure.
Proteins - 1 Jan 1992
Veerapandian B, Gilliland G L, Raag R, Svensson A L, Masui Y, Hirai Y, Poulos T L
Abstract excerpt
The molecular structure of interleukin-1 beta, a hormone-like cytokine with roles in several disease processes, has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. The framework of this molecule consists of 12 antiparallel beta-strands exhibiting pseudo-3-fold symmetry. Six of the strands make up a beta-barrel with polar residues concentrated at either end. Analysis of the...
Topics
- Humans
- Hydrogen Bonding
- Interleukin-1
- Models, Molecular
- Mutation
- Protein Conformation
- Structure-Activity Relationship