Molecular epidemiology: a new perspective for the study of toxic exposures in man. A consideration of the influence of genetic susceptibility factors on risk in different lung cancer histologies.

Abstract excerpt

This data in the aggregate suggests that the 3 best studied genetic susceptibility factors (CYP2D6 extensive metabolizers, GST mu null phenotype, and CYP1A1 "mutant" alleles in Asians only) constitute greater risk factors for the more smoking related histologies of lung cancer, but not for adenocarcinoma. The epidemiologic evidence for a these genetic susceptibility factors in tobacco-related cancer is suggestive...

Topics

• Disease Susceptibility
• Environmental Exposure
• Genotype
• Humans
• Lung Neoplasms
• Molecular Epidemiology
• Pharmacogenetics
• Phenotype
• Risk Factors