Article
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jan 2000
Sobti R C, Sharma S, Joshi A, Jindal S K, Janmeja A
Abstract excerpt
This case-control study was conducted to examine the association between the CYP1A1 and CYP2D6 genotypes and lung cancer risk among North Indians. The estimated relative risk for lung cancer associated with the CYP1A1 Val/Val allele was 2.68, and was four-fold when cases with small cell lung cancer (SCLC) were considered alone. With regard to the metabolism of debrisoquine, no poor metabolizers were found amongst...
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