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Article

Human Lung Carcinogen--DNA Adduct Levels Mediated by Genetic Polymorphisms In Vivo

21 Jun 1995

Abstract excerpt

BACKGROUND: Cancer risk from exposure to tobacco smoke varies widely from person to person, depending in part on the status of particular genes and acquired susceptibilities. Certain genes determine how cells activate and detoxify carcinogens. Activated carcinogen metabolites may bind to DNA and form DNA adducts (e.g., 7-methyl-2'-deoxyguanosine-3'-monophosphate [7-methyl-dGMP] and polycyclic aromatic...

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PMID: 7666479
DOI: 10.1093/jnci/87.12.902

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