Article
Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens.
Annali dell'Istituto superiore di sanita - 1 Jan 1991
Caporaso N
Abstract excerpt
Molecular epidemiology approaches are being employed to examine the validity and elucidate the basis for hypothesized associations of genetic susceptibility factors with common malignancies due to carcinogen exposure. This approach integrates traditional epidemiologic study designs with state-of-the-art laboratory assays. Advantages of this strategy include the possibility of gaining insight into mechanisms and...
Topics
- Biotransformation
- Carcinogens, Environmental
- Case-Control Studies
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Environmental Exposure
- Epidemiologic Methods
- Genetic Predisposition to Disease
- Heterozygote