Article
Interactions between genetic predisposition and environmental toxicants for development of lung cancer.
Environmental and molecular mutagenesis - 1 Jan 1997
el-Zein R, Conforti-Froes N, Au W W
Abstract excerpt
Significant interindividual variations in health outcome may be caused by the inheritance of variant polymorphic genes, such as CYP2D6 and CYP2E1 for activation, and GSTM1 and GSTT1 for detoxification of chemicals. However, mechanistic studies linking the inheritance of predisposing genes with ge...
Topics
- Adenocarcinoma
- Case-Control Studies
- Chromosome Aberrations
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP2E1
- Environmental Exposure
- Genetic Predisposition to Disease
- Glutathione Transferase
- Homozygote
- Humans
- In Situ Hybridization, Fluorescence