Article
Phase I trial of recombinant macrophage colony-stimulating factor and recombinant gamma-interferon: toxicity, monocytosis, and clinical effects.
Cancer research - 1 Aug 1994
Weiner L M, Li W, Holmes M, Catalano R B, Dovnarsky M, Padavic K, Alpaugh R K
Abstract excerpt
Macrophage colony-stimulating factor (M-CSF) is a known inducer of proliferation and differentiation of cells of the mononuclear phagocyte lineage, and gamma-interferon (gamma-IFN) is a known activator of mononuclear phagocytes. In this Phase I clinical trial of combined therapy with M-CSF and ga...
Topics
- Adult
- Aged
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Humans
- Interferon-gamma
- Leukocytosis
- Macrophage Colony-Stimulating Factor
- Male
- Middle Aged
- Monocytes
- Neoplasms
- Phenotype
- Recombinant Proteins