Role of macrophage colony-stimulating factor in the differentiation and expansion of monocytes and dendritic cells from CD34+ progenitor cells.

doi:10.1007/BF02787358

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Article

Role of macrophage colony-stimulating factor in the differentiation and expansion of monocytes and dendritic cells from CD34+ progenitor cells.

Medical oncology (Northwood, London, England) - 1 Apr 1999

Kamps A W, Hendriks D, Smit J W, Vellenga E

Abstract excerpt

The present study focused on whether it is possible to expand monocytic cells from CD34+ progenitor cells by using macrophage colony-stimulating factor (M-CSF) in the absence and presence of mast cell growth factor (MGF) and IL-6. It was demonstrated that CD34+ cells differentiate without expansion to functional mature monocytic cells in the presence of M-CSF or combinations of M-CSF plus IL-6 and MGF. A...

Topics

Antigens, CD34
Cell Differentiation
Cell Division
Dendritic Cells
Humans
Immunoenzyme Techniques
Interleukin-6
Macrophage Colony-Stimulating Factor
Monocytes
Phagocytosis
Phenotype
Stem Cell Factor
Stem Cells

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PMID: 10382942
DOI: 10.1007/BF02787358

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