Article
Administration of recombinant IL-4 to humans regulates gene expression, phenotype, and function in circulating monocytes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1992
Wong H L, Lotze M T, Wahl L M, Wahl S M
Abstract excerpt
As a multifunctional cytokine that can augment certain T cell responses, IL-4 is being evaluated currently as a possible therapeutic agent in the treatment of cancer patients. In this report, PBMC were isolated from such patients before and after IL-4 therapy and were analyzed for phenotypic and functional alterations. Differential blood counts showed that the relative percentages of lymphocytes and, to a lesser...
Topics
- Antigens, Differentiation, B-Lymphocyte
- Cells, Cultured
- Dinoprostone
- Gene Expression Regulation
- Humans
- Interleukin-1
- Interleukin-4
- Monocytes
- Phenotype
- Receptors, Fc
- Receptors, IgE