Synergistic suppression of the clonogenicity of U937 leukemic cells by combinations of recombinant human interleukin 4 and granulocyte colony-stimulating factor.

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Article

Synergistic suppression of the clonogenicity of U937 leukemic cells by combinations of recombinant human interleukin 4 and granulocyte colony-stimulating factor.

Experimental hematology - 1 Nov 1992

Maekawa T, Sonoda Y, Kuzuyama Y, Inazawa J, Kimura S, Nakamichi K, Abe T

Abstract excerpt

The actions and interactions of purified recombinant human (rh) interleukin 4 (IL-4) and granulocyte colony-stimulating factor (G-CSF) on the clonogenicity of human leukemic cell line U937 were studied in vitro. Parameters analyzed were the suppression of stem cell generation using sequential clonal cultures, alterations of surface antigen expression, and morphological changes. IL-4 alone (10 U/ml) and G-CSF...

Topics

Antibodies
Cell Division
Drug Synergism
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Interferon-gamma
Interleukin-4
Interleukin-6
Leukemia, Myeloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophage-1 Antigen

Phenotype

Recombinant Proteins

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Tumor Stem Cell Assay

Source

Open in PubMed

Identifiers

PMID: 1385197

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1385197-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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