Article
Cytokine regulation of human monocyte differentiation in vitro: the tumor-cytotoxic phenotype induced by macrophage colony-stimulating factor is developmentally regulated by gamma-interferon.
Cancer research - 1 Jun 1993
Munn D H, Armstrong E
Abstract excerpt
In this study we continue our examination of the unique form of antibody-dependent antitumor cytotoxicity (ADCC) which develops when human monocytes are exposed to macrophage colony-stimulating factor (MCSF) in vitro. This form of ADCC is not present in fresh monocytes and emerges only as monocyt...
Topics
- Antibody-Dependent Cell Cytotoxicity
- Cell Differentiation
- Cell Division
- Humans
- Immunophenotyping
- Interferon-gamma
- Lymphocyte Activation
- Macrophage Activation
- Macrophage Colony-Stimulating Factor
- Macrophages
- Monocytes
- Nitroblue Tetrazolium
- Oxidation-Reduction
- Phenotype
- Reactive Oxygen Species
- Receptor, Macrophage Colony-Stimulating Factor