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Article

Biologic response modulation by tumor necrosis factor alpha (TNF alpha) in a phase Ib trial in cancer patients.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Sept 1997

Logan T F, Gooding W E, Whiteside T L, Ernstoff M S, Kaplan S S, Miketic L, Vlock D R, Tompkins C, Wood D L, Nadler P I, Kirkwood J M

Abstract excerpt

During a phase I study of recombinant human tumor necrosis factor (TNF) in cancer patients, serial immune studies were performed and analyzed for effects of TNF. The TNF (specific activity 9.6 x 10(6) U/mg protein, < 5.0 endotoxin units/mg protein) was given over 2 h intravenously on days 1, 8-12...

Topics

Dose-Response Relationship, Immunologic
Drug Administration Schedule
Humans
Immunologic Factors
Immunotherapy
Interferon-gamma
Interleukin-2
Killer Cells, Lymphokine-Activated
Monocytes
Multivariate Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms

Phenotype

Superoxides

T-Lymphocyte Subsets

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 9336746
DOI: 10.1097/00002371-199709000-00008

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9336746-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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