Article
Phase I evaluation of combination therapy with interleukin 2 and gamma-interferon.
Cancer research - 1 Aug 1991
Weiner L M, Padavic-Shaller K, Kitson J, Watts P, Krigel R L, Litwin S
Abstract excerpt
Recombinant interleukin 2 (IL-2) is a potent inducer of lymphokine-activated killer (LAK) activity directed against autologous and allogeneic tumors; these effects are mediated by CD3-negative, CD56-positive, and CD16-positive lymphocytes. Although IL-2 therapy has been associated with clinical responses, particularly in patients with renal cell carcinoma and melanoma, these responses have occurred with high,...
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