Phase I evaluation of combination therapy with interleukin 2 and gamma-interferon.

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Article

Phase I evaluation of combination therapy with interleukin 2 and gamma-interferon.

Cancer research - 1 Aug 1991

Weiner L M, Padavic-Shaller K, Kitson J, Watts P, Krigel R L, Litwin S

Abstract excerpt

Recombinant interleukin 2 (IL-2) is a potent inducer of lymphokine-activated killer (LAK) activity directed against autologous and allogeneic tumors; these effects are mediated by CD3-negative, CD56-positive, and CD16-positive lymphocytes. Although IL-2 therapy has been associated with clinical responses, particularly in patients with renal cell carcinoma and melanoma, these responses have occurred with high,...

Topics

Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Cytotoxicity, Immunologic
Drug Evaluation
Female
Humans
Interferon-gamma
Interleukin-2
Killer Cells, Lymphokine-Activated
Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Male

Middle Aged

Neoplasms

Phenotype

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 1906779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1906779-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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