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Article

The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia.

The Journal of clinical investigation - 1 Jun 1991

Ahuja H, Bar-Eli M, Arlin Z, Advani S, Allen S L, Goldman J, Snyder D, Foti A, Cline M

Abstract excerpt

DNA from 135 patients with chronic myelogenous leukemia (CML) at various clinical stages and Philadelphia (Ph1) chromosome positive acute lymphoblastic leukemia was investigated for alterations in a variety of proto-oncogenes which have been implicated in the evolution of CML from its chronic phase to blast crisis. The most common genetic change found in the evolution of typical Ph1 chromosome positive CML to...

Topics

Blotting, Northern
Blotting, Southern
DNA, Neoplasm
Gene Expression Regulation, Neoplastic
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Accelerated Phase
Leukemia, Myeloid, Chronic-Phase
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Transcription, Genetic

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 2040694
DOI: 10.1172/JCI115234
PMCID: PMC296960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2040694-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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