Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low frequency of ras oncogene mutations in Philadelphia-positive acute leukemia and report of a novel mutation H61 Leu in a single case.

Leukemia - 1 Apr 1992

Urbano-Ispizua A, Gill R, Matutes E, Levi S, Wiedemann L M, Catovsky D, Marshall C J

Abstract excerpt

Activating ras mutations are frequent (25-60%) in chronic myelomonocytic leukemia (CMML) and in acute myeloid leukemia (AML) (30%), in contrast to chronic myeloid leukemia (CML) in which the incidence is very low (0-3%). This might reflect that the leukemic cell in CML is at a level of differentiation in which ras gene activation is not involved or, alternatively, might be due to the presence in CML of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to Leucine

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Polymerase Chain Reaction

Share to Transcriptional Activation

Source

Identifiers

PMID: 1588796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low frequency of ras oncogene mutations in Philadelphia-positive acute leukemia and report of a novel mutation H61 Leu in a single case.PMID 1588796Read ↗

Specific point mutations that activate v-abl are not found in Philadelphia-negative chronic myeloid leukaemia, Philadelphia-negative acute lymphoblastic leukaemia or blast transformation of chronic myeloid leukaemia.Semantic proximity Read ↗

RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia.Semantic proximity Read ↗

The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing.Semantic proximity Read ↗

Absence of N-ras mutations in myeloid and lymphoid blast crisis of chronic myeloid leukemia.Semantic proximity Read ↗

Mutation analysis of the ras gene in myelocytic leukemia by polymerase chain reaction and oligonucleotide probes.Semantic proximity Read ↗

Analysis of ras gene mutations in childhood myeloid leukaemia.Semantic proximity Read ↗

Frequency of RAS and p53 mutations in acute promyelocytic leukemias.Semantic proximity Read ↗

N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance.Semantic proximity Read ↗

Are aberrant BCR--ABL transcripts more common than previously thought?Semantic proximity Read ↗

Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia.Semantic proximity Read ↗

Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes.Semantic proximity Read ↗

Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.