Article
Low frequency of ras oncogene mutations in Philadelphia-positive acute leukemia and report of a novel mutation H61 Leu in a single case.
Leukemia - 1 Apr 1992
Urbano-Ispizua A, Gill R, Matutes E, Levi S, Wiedemann L M, Catovsky D, Marshall C J
Abstract excerpt
Activating ras mutations are frequent (25-60%) in chronic myelomonocytic leukemia (CMML) and in acute myeloid leukemia (AML) (30%), in contrast to chronic myeloid leukemia (CML) in which the incidence is very low (0-3%). This might reflect that the leukemic cell in CML is at a level of differenti...
Topics
- Codon
- Fusion Proteins, bcr-abl
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Glutamine
- Humans
- Leucine
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Acute
- Leukemia, Myelomonocytic, Chronic
- Mutation
- Polymerase Chain Reaction
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Transcriptional Activation