Article
Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia.
Annals of hematology - 1 Jun 2014
Reuter Christoph W M, Krauter Jürgen, Onono Fredrick O, Bunke Tania, Damm Frederik, Thol Felicitas, Wagner Katharina, Göhring Gudrun, Schlegelberger Brigitte, Heuser Michael, Ganser Arnold, Morgan Michael A
Abstract excerpt
Transforming mutations in RAS genes are commonly found in human malignancies, including myeloid leukemias. To investigate the incidence, spectrum, and distribution of activating K- and N-RAS mutations in cytogenetically normal acute myeloid leukemia (CN-AML) patients, 204 CN-AML patients were screened. Activating K- and N-RAS mutations were detected in 3 of 204 (1.5 %) and 22 of 204 (10.8 %) CN-AML samples,...
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