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Article

Role of DNA polymerase eta in the UV mutation spectrum in human cells.

The Journal of biological chemistry - 23 May 2003

Stary Anne, Kannouche Patricia, Lehmann Alan R, Sarasin Alain

Abstract excerpt

In humans, inactivation of the DNA polymerase eta gene (pol eta) results in sunlight sensitivity and causes the cancer-prone xeroderma pigmentosum variant syndrome (XP-V). Cells from XP-V individuals have a reduced capacity to replicate UV-damaged DNA and show hypermutability after UV exposure. Biochemical assays have demonstrated the ability of pol eta to bypass cis-syn-cyclobutane thymine dimers, the most...

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PMID: 12644471
DOI: 10.1074/jbc.M211838200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of DNA polymerase eta in the UV mutation spectrum in human cells.PMID 12644471Read ↗

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