Article
Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells.
Journal of molecular biology - 6 Oct 1995
Marionnet C, Benoit A, Benhamou S, Sarasin A, Stary A
Abstract excerpt
To study the relationships between mutagenesis and carcinogenesis, we compared the mutations and their frequency induced by ultraviolet irradiation at 254 nm (UV-C) in XP-D (GM-08207B/XP6BE), TTD/XP-D (TTD1VI-LAS-KMT11) and wild-type (MRC-5V1) human cells. XP-D and TTD/XP-D cells, mutated in the...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Cell Line, Transformed
- Cell Survival
- DNA Repair
- Fibroblasts
- Genetic Vectors
- Hair Diseases
- Humans
- Lac Operon
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Point Mutation
- Ultraviolet Rays
- Xeroderma Pigmentosum