Article
Replication of a Moloney murine leukemia virus mutant lacking the ELP binding site.
Virology - 15 Aug 1994
Coulombe J, Dubé M, Gray D A
Abstract excerpt
A mutant Moloney murine leukemia virus was created in which the binding site for the embryonal long terminal repeat binding protein had been replaced with a synthetic linker sequence. The virus was found to replicate normally in murine 3T3 fibroblasts, and the mutation was stably transmitted throughout repeated passages. The binding site is therefore dispensable with respect to viral replication. Titers of the...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Binding Sites
- Carrier Proteins
- DNA-Binding Proteins
- Embryonal Carcinoma Stem Cells
- Homeodomain Proteins
- Mice
- Molecular Sequence Data
- Moloney murine leukemia virus