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Article

Mutations affecting the cytoplasmic domain of the Moloney murine leukemia virus envelope protein: rapid reversion during replication.

Virus research - 1 Mar 1996

Granowitz C, Berkowitz R D, Goff S P

Abstract excerpt

Five premature termination mutations and five missense mutations were introduced into the portion of cloned Moloney murine leukemia virus (M-MuLV) DNA encoding the Env cytoplasmic domain. All of the mutant DNAs gave rise to replication-competent virus after transfection of NIH/3T3 cells, but several of the mutant DNAs scored as replication-defective when introduced into Rat2 cells. Cell lines stably expressing...

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PMID: 8725100
DOI: 10.1016/0168-1702(95)01278-8

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