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Article

Comprehensive mutational analysis of the Moloney murine leukemia virus envelope protein.

Journal of virology - 1 Dec 2001

Rothenberg S M, Olsen M N, Laurent L C, Crowley R A, Brown P O

Abstract excerpt

The envelope (Env) protein of Moloney murine leukemia virus is the primary mediator of viral entry. We constructed a large pool of insertion mutations in the env gene and analyzed the fitness of each mutant in completing two critical steps in the virus life cycle: (i) the expression and delivery of the Env protein to the cell surface during virion assembly and (ii) the infectivity of virions displaying the mutant...

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Identifiers

PMID: 11689666
DOI: 10.1128/JVI.75.23.11851-11862.2001
PMCID: PMC114771

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