Article
Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity.
Genes & development - 1 Feb 1990
Speck N A, Renjifo B, Golemis E, Fredrickson T N, Hartley J W, Hopkins N
Abstract excerpt
Transcriptional enhancers of replication-competent mouse C-type retroviruses are potent determinants of the distinct disease-inducing phenotypes of different viral isolates and can also strongly influence the incidence and latent period of disease induction. To study the contribution of individua...
Topics
- Animals
- Base Sequence
- DNA, Viral
- Enhancer Elements, Genetic
- Leukemia, Experimental
- Mice
- Molecular Sequence Data
- Moloney murine leukemia virus
- Mutation
- Repetitive Sequences, Nucleic Acid
- Time Factors