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Article

Forced lytic replication impairs host colonization by a latency-deficient mutant of murine gammaherpesvirus-68.

The Journal of general virology - 1 Jan 2004

May Janet S, Coleman Heather M, Smillie Belinda, Efstathiou Stacey, Stevenson Philip G

Abstract excerpt

A regulated switch between latent and lytic gene expression is common to all known herpesviruses. However, the effects on host colonization of altering this switch are largely unknown. We deregulated the transcription of the gene encoding the major lytic transactivator of murine gammaherpesvirus-68, ORF50, by inserting a new and powerful promoter element in its 5' untranslated region. In vitro, the mutant virus...

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PMID: 14718628
DOI: 10.1099/vir.0.19599-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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