Simple tandem repeat allelic deletions confirm the preferential loss of distal chromosome 6q in melanoma.

doi:10.1002/ijc.2910580210

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Article

Simple tandem repeat allelic deletions confirm the preferential loss of distal chromosome 6q in melanoma.

International journal of cancer - 15 Jul 1994

Walker G J, Palmer J M, Walters M K, Nancarrow D J, Parsons P G, Hayward N K

Abstract excerpt

Karyotypic analysis, loss of somatic heterozygosity, microcell fusion and cDNA transfection studies have provided compelling evidence that at least one tumour suppressor gene for melanoma resides on chromosome 6. In an attempt to further define the regions to which these putative suppressor genes...

Topics

Alleles
Chromosome Deletion
Chromosomes, Human, Pair 6
DNA, Neoplasm
Genetic Markers
Heterozygote
Humans
Melanoma
Repetitive Sequences, Nucleic Acid
Tumor Cells, Cultured

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