Article
Simple tandem repeat allelic deletions confirm the preferential loss of distal chromosome 6q in melanoma.
International journal of cancer - 15 Jul 1994
Walker G J, Palmer J M, Walters M K, Nancarrow D J, Parsons P G, Hayward N K
Abstract excerpt
Karyotypic analysis, loss of somatic heterozygosity, microcell fusion and cDNA transfection studies have provided compelling evidence that at least one tumour suppressor gene for melanoma resides on chromosome 6. In an attempt to further define the regions to which these putative suppressor genes map, we have carried out loss of heterozygosity (LOH) studies on DNA from 25 fresh melanoma tumours for 9 simple...
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