Article
Evidence of allelic imbalance of chromosome 6 in human astrocytomas.
Neurology - 1 Mar 1994
Liang B C, Ross D A, Greenberg H S, Meltzer P S, Trent J M
Abstract excerpt
Transfer of human chromosome 6 can suppress the malignant phenotype of melanoma. Because of the neural ectoderm origin of melanoma and since up to 30% of gliomas have abnormalities involving chromosome 6, we performed restriction fragment length polymorphism analysis to determine the importance of allelic loss on chromosome 6 in gliomas. DNA samples from tumor and white blood cells were obtained from patients...
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