Article
Linkage analysis in familial melanoma kindreds to markers on chromosome 6p.
International journal of cancer - 15 Dec 1994
Walker G J, Nancarrow D J, Walters M K, Palmer J M, Weber J L, Hayward N K
Abstract excerpt
Malignant melanoma occurs as a familial cancer in 5%-10% of cases, where it segregates in a manner consistent with autosomal dominant inheritance. Evidence from cytogenetics, fine mapping studies of deletions in melanomas and recent linkage studies supports the location of a human melanoma predisposition gene on the short arm of chromosome 9. Evidence also exists for a melanoma gene on Ip, indicating genetic...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Disease Susceptibility
- Family
- Genetic Markers
- Genotype
- HLA Antigens
- Haplotypes
- Humans
- Lod Score
- Melanoma
- Queensland