Article
Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval.
Genes, chromosomes & cancer - 1 Sept 2004
Walker Graeme J, Indsto James O, Sood Raman, Faruque Mezbah U, Hu Ping, Pollock Pam M, Duray Paul, Holland Elizabeth A, Brown Kevin, Kefford Richard F, Trent Jeffrey M, Mann Graham J, Hayward Nicholas K
Abstract excerpt
Loss of the short arm of chromosome 1 is frequently observed in many tumor types, including melanoma. We recently localized a third melanoma susceptibility locus to chromosome band 1p22. Critical recombinants in linked families localized the gene to a 15-Mb region between D1S430 and D1S2664. To map the locus more finely we have performed studies to assess allelic loss across the region in a panel of melanomas...
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