Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.

Article

Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1996

Klotz E L, Storb U

Abstract excerpt

Previous experiments have suggested an important role for the Ig enhancers and transcription in targeting somatic hypermutation. To determine whether the requirement of the enhancers is Ig chain specific, we analyzed two lambda 2 light chain transgenes under the control of different enhancers, ei...

Topics

Animals
Cell Line
Enhancer Elements, Genetic
Gene Expression Regulation
Immunoglobulin Heavy Chains
Immunoglobulin lambda-Chains
Introns
L Cells
Mice
Mice, Transgenic
Mutation
Transgenes

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