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Article

Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2009

Kim Eunkyung, Kwak Heechun, Ahn Kwangseog

Abstract excerpt

Antigenic peptides presented by MHC class I molecules are generated mainly by the proteasome in the cytosol. Several cytosolic aminopeptidases further trim proteasomal products to form mature epitopes or individual amino acids. However, the distinct function of cytosolic aminopeptidases in MHC class I Ag processing remains to be elucidated. In this study, we show that cytosolic aminopeptidases differentially...

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PMID: 19917696
DOI: 10.4049/jimmunol.0901489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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