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Article

Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.

The Journal of biological chemistry - 15 Jun 1992

Yang Y, Früh K, Chambers J, Waters J B, Wu L, Spies T, Peterson P A

Abstract excerpt

The mutant murine lymphoma cell line RMA-S is unable to present endogenous antigens due to its inability to efficiently assemble class I major histocompatibility complex molecules and antigenic peptides. Therefore, it has been suggested that RMA-S cells are defective either in peptide generation or in peptide transport into the endoplasmic reticulum, where class I major histocompatibility complex molecule...

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PMID: 1339432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.PMID 1339432Read ↗

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Quantitative measurement of the requirement of diverse protein degradation pathways in MHC class I peptide presentationSemantic proximity Read ↗

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The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation.Semantic proximity Read ↗

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Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter.Semantic proximity Read ↗

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