Article
Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.
The Journal of biological chemistry - 15 Jun 1992
Yang Y, Früh K, Chambers J, Waters J B, Wu L, Spies T, Peterson P A
Abstract excerpt
The mutant murine lymphoma cell line RMA-S is unable to present endogenous antigens due to its inability to efficiently assemble class I major histocompatibility complex molecules and antigenic peptides. Therefore, it has been suggested that RMA-S cells are defective either in peptide generation...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport, Active
- Carrier Proteins
- Histocompatibility Antigens Class I
- Major Histocompatibility Complex
- Membrane Proteins
- Mice
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sequence Homology, Nucleic Acid
- Tumor Cells, Cultured