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Article

Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants.

The Journal of experimental medicine - 1 Apr 1993

Kittlesen D J, Brown L R, Braciale V L, Sambrook J P, Gething M J, Braciale T J

Abstract excerpt

Human lymphoblastoid cells transiently expressing the hemagglutinin (HA) glycoprotein of influenza virus are rapidly and efficiently recognized by CD4+ HA-specific T lymphocytes. This endogenous presentation pathway is sensitive to chloroquine and is therefore likely related to the classical class II major histocompatibility complex (MHC) exogenous pathway of antigen presentation. In this study we have examined a...

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Identifiers

PMID: 8096235
DOI: 10.1084/jem.177.4.1021
PMCID: PMC2190981

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