Article
Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants.
The Journal of experimental medicine - 1 Apr 1993
Kittlesen D J, Brown L R, Braciale V L, Sambrook J P, Gething M J, Braciale T J
Abstract excerpt
Human lymphoblastoid cells transiently expressing the hemagglutinin (HA) glycoprotein of influenza virus are rapidly and efficiently recognized by CD4+ HA-specific T lymphocytes. This endogenous presentation pathway is sensitive to chloroquine and is therefore likely related to the classical clas...
Topics
- Amino Acid Sequence
- Antigen-Presenting Cells
- B-Lymphocytes
- Base Sequence
- Biological Transport
- CD4-Positive T-Lymphocytes
- Cell Line
- Cell Line, Transformed
- DNA
- Flow Cytometry
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Histocompatibility Antigens Class II
- Humans